Have you noticed the problem ________ he is now in low spirits?________ come?

Awhere;What Bthat;How

Cin which;For Dwhat;As

 

B

【解析】that引導(dǎo)同位語(yǔ)從句,用以說明problem的內(nèi)容;后面的How come“怎么會(huì)那樣為固定搭配。

 

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